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We found that 19 metabolites were significantly increased by MTX, whereas 12 were decreased in response to the drug treatment ( Figure 1A and Supplementary Table 4 )

Sitagliptin was granted FDA approval on 16 October 2006 (National Center for Biotechnology Information, 2023f)

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Firstly, the ROR algorithm and Chi-Square Test/Fishers exact test were employed to analyze differences in adverse events across subgroups